Working Group Clarner
Multiple sclerosis is one of the most common neurological diseases in young adults. In the course of the disease, immune cells migrate into the central nervous system, often in relapses.
Prof. Dr. rer. nat. Tim Clarner
Research
Although almost all therapeutic approaches for multiple sclerosis aim to prevent this migration, the basic triggers and mechanisms of these pathological processes are still poorly understood.
We are therefore interested in the processes that take place at the boundary layer between the vascular system and the CNS, the so-called blood-brain barrier, and how these processes can be influenced.
In addition to this neuroinflammatory component of the disease, cyto-degenerative aspects also play an important role in the progression of neurological symptoms. In particular, the loss of the myelin layer surrounding the nerve fibres is a hallmark of multiple sclerosis. In this context, we are investigating processes that lead to the selective loss of myelin-forming oligodendrocytes.
Thus, future treatments could aim to limit or prevent this loss and thus slow down the progression of the disease.
Reactive astrocytes as modulators of lesion development in MS
Although the exact causes for the development of lesions in MS are still largely unclear, astrocytes seem to play a crucial role in this process.
Lipocalin 2 as a modulator of neuroinflammation and the blood-brain barrier
What is the role of lipocalin 2 in lesion development and progression? And how do intracellular signaling pathways as well as receptors for LCN2 behave under inflammatory conditions in the CNS?
AnDi: Anatomy Digital
Digitization enables us to make the knowledge of the human body taught in the dissection course accessible to a wider audience and opens up new teaching opportunities for medical professionals.
Secretariat
Scientists
We are looking for committed PostDocs and PhD students to set up our new research group in Bonn.
If you are interested, please contact Prof. Dr. Clarner.
